iTV-Studio-16 includes one master iTV-Studio-4 and two slave iTV-Studio-6's as far as 200 feet away from the master.

The three switcher control panels are centrally located (via Ethernet cables), where the program director can choose from 16 cameras.

One HDMI input on the master iTV-Studio is optionally used for an iTV-Laptop-2 sending graphics and media files or remote guests via Skype.